Early Cancer Detection Research and Grants

Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial

The PLCO Cancer Screening Trial began in 1992 to determine whether various screening exams might reduce death risk for cancers of the lung, colorectum, prostate, or ovary.  The University of Colorado, one of 10 centers nationally, has enrolled over 13,000 participants.  Participants were randomly selected to receive screening tests annually for six years or to follow their regular medical care.  Long-term follow-up of the PLCO participants continues.  (PI David Crawford, funded by NCI)   

The National Lung Screening Trial

The NLST is a randomized controlled study comparing spiral CT and standard chest x-ray as screening to determine if either modality decreases lung cancer specific mortality.  50,000 participants are enrolled at 10 centers around the country, of which over 3700 are followed by University of Colorado.  Screening is now complete and the follow-up phase of the trial is slated to close in 2009.  (PI David Crawford, funded by NCI)

Lung Cancer Early Detection Biomarkers

Investigators in the University of Colorado Lung Cancer Specialized Program of Research Excellence (SPORE) are studying biomarkers for the early detection of lung cancer.  Collections of sputum samples from over 3000 people at high risk from lung cancer has allowed analyses of cellular and molecular changes in sputum cells that predict lung cancer risk.  (PI Paul Bunn, funded by NCI)

Colorado Colorectal Screening Program

The CCSP is a novel cancer detection and screening program operated by the University of Colorado Comprehensive Cancer Center.  The program, operated in collaboration with community clinics across Colorado,  pays for colonoscopic screening for 3000 Coloradans each year, navigates them through screening and care, and pays for medical treatment for cancers that are detected. (PI Tim Byers, funded by state tobacco tax)