University of Colorado Cancer Center Gene Expression Shared Core Service
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The Gene Expression Core is dedicated to providing state-of-the-art facilities and technical support and services for analysis of gene expression, which will allow UCCC members to be on the cutting edge of cancer research.
The Gene Expression Core is comprised of:
Core Objectives
- Analyze gene expression using both pre-made and custom designed oligonucleotide arrays
- Facilitate gene discovery
- Accurately quantitate gene expression using real time PCR and GenomeLab GeXP technology
- Provide support for data analysis and bioinformatics by our data mining tool and our data analysis capabilities
- Remain committed to using a variety of approaches for expression analysis
- Provide consultation and educational services to help those members with limited knowledge on microarray technology and to bring the Core customers up to date as technology advances
The Gene Expression Core was established in response to the technological advances in gene array, as well as the demand for high throughput expression analysis and genomic investigation to investigate pathogenesis, therapeutics, genetic susceptibility and gene discovery in cancer research. The informatics aspect is of paramount importance, and five distinct analysis programs, as well as a network, are used to store, share and analyze the data.
To date, the Core is one of the highest volume Affymetrix microarray facilities in academia in the country, having performed more than 10,900 microarrays including test arrays over seven years for nearly 250 investigators. On average, 85% of the users are UCCC members.